Many psychoactive drugs are used recreationally, particularly by young people. This use has led to many different classes of drugs being banned under national laws and international conventions in an attempt to reduce use.  However the regulations on drugs such as cannabis, MDMA and psychedelics are much more stringent than their harms require. This has effectively censored research over the past 50 years in a manner similar to the way the church limited scientific progress before The Enlightenment. This has had a serious detrimental impact on neuroscience research and the treatment of brain disorders such as depression and post-traumatic stress disorder. My talk will argue it is time to change – for neuroscience to undergo its Enlightenment.